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It is estimated that burnout affects 30 -50% of healthcare providers at any time. Too often, burnout is considered a personal problem; however, in healthcare, burnout affects the entire system. Burnout has significant impact in healthcare, including reduced quality patient care, patient and staff safety, patient satisfaction, and increased staff turnover. There is also a statistically significant correlation between nurse burnout and increased healthcare-associated infections. Burnout, while a personal problem, is also a system problem that impacts staff, patients, and profits. In infectious disease control, learning how to prevent and recover from burnout can change your practice.