SharePoint Site Collection Governance

While working with a client recently we came upon a seemingly simple question. How big, in terms of business scope, should a SharePoint site collection be? The question is a good one because it gets at the heart of how to architect your SharePoint Solution. You can decide on a model with only a few site collections — or one where there are a large number of site collections. In this article, I’ll take you through a process of evaluating the needs of your business units and how to design a strategy and make individual decisions.

http://www.intranetjournal.com/articles/200804/ij_04_07_08a.html